Thursday, May 7, 2009

Exposure as part of a systems approach for assessing risk

Source: Environmental Health Perspectives, April 2009
"Exposure science, when applied in an integrated systems approach for risk assessment, can be used to inform and prioritize toxicity testing, describe risks, and verify the outcomes of testing. Exposure research in several areas will be needed to achieve the NRC vision. For example, models are needed to screen chemicals based on exposure. Exposure, dose-response, and biological pathway models must be developed and seamlessly linked. Advanced computational approaches are required for dose reconstruction. Monitoring methods are needed that easily measure exposure, internal dose, susceptibility, and biological outcome. Finally, population monitoring studies are needed to interpret toxicity test results in terms of real-world risk."